Ontology highlight
ABSTRACT:
SUBMITTER: King GA
PROVIDER: S-EPMC6711709 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
King Grant A GA Goodman Jay S JS Schick Jennifer G JG Chetlapalli Keerthana K Jorgens Danielle M DM McDonald Kent L KL Ünal Elçin E
eLife 20190809
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism. Using time-lapse fluorescence microscopy in budding yeast, we found that nuclear senescence factors - including protein aggregates, extrachromosomal ribosomal DNA circles, and abnormal nucleolar material - are sequestered away from chromosomes during meiosis II and ...[more]