Ontology highlight
ABSTRACT:
SUBMITTER: Kim JY
PROVIDER: S-EPMC6711970 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Kim Jin Yong JY Ohn Jungyoon J Yoon Ji-Seon JS Kang Bo Mi BM Park Minji M Kim Sookyung S Lee Woochan W Hwang Sungjoo S Kim Jong-Il JI Kim Kyu Han KH Kwon Ohsang O
Nature communications 20190827 1
The maintenance of genetic integrity is critical for stem cells to ensure homeostasis and regeneration. Little is known about how adult stem cells respond to irreversible DNA damage, resulting in loss of regeneration in humans. Here, we establish a permanent regeneration loss model using cycling human hair follicles treated with alkylating agents: busulfan followed by cyclophosphamide. We uncover the underlying mechanisms by which hair follicle stem cells (HFSCs) lose their pool. In contrast to ...[more]