Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC6712175 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Chen Xuebing X Lu Jiancong J Zhao Xu X Chen Chuanxiang C Qiao Dongfang D Wang Huijun H Yue Xia X
Frontiers in cellular neuroscience 20190821
Methamphetamine (MA) is a widely abused psychoactive drug that primarily damages the nervous system. However, the involvement of MA in the survival of microglia remains poorly understood. CCAAT-enhancer binding protein (C/EBP-β) is a transcription factor and an important regulator of cell apoptosis. Lipocalin2 (lcn2) is a known apoptosis inducer and is involved in many cell death processes. We hypothesized that C/EBP-β is involved in MA-induced lcn2-mediated microglial apoptosis. To test this hy ...[more]