Ontology highlight
ABSTRACT:
SUBMITTER: Teixeira BVF
PROVIDER: S-EPMC6713189 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Teixeira Bárbara Velame Ferreira BVF Teles André Lacerda Braga ALB Silva Suellen Gonçalves da SGD Brito Camila Carane Bitencourt CCB Freitas Humberto Fonseca de HF Pires Acássia Benjamim Leal ABL Froes Thamires Quadros TQ Castilho Marcelo Santos MS
Journal of enzyme inhibition and medicinal chemistry 20191201 1
Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity. In order to develop novel therapeutic alternatives to fight this ailment, pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHF-TS) have been targeted, once <i>Leishmania</i> is auxotrophic for folates. Although PTR1 and DHFR-TS from other protozoan parasites have been studied, their homologs in <i>Leishmania chagas ...[more]