Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen MK
PROVIDER: S-EPMC6713499 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nguyen Minh Khanh MK Huynh Cong Truc CT Gilewski Alex A Wilner Samantha E SE Maier Keith E KE Kwon Nicholas N Levy Mathew M Alsberg Eben E
Science advances 20190828 8
Small interfering RNA (siRNA) has found many applications in tissue regeneration and disease therapeutics. Effective and localized siRNA delivery remains challenging, reducing its therapeutic potential. Here, we report a strategy to control and prolong siRNA release by directly tethering transfection-capable siRNA to photocrosslinked dextran hydrogels. siRNA release is governed via the hydrolytic degradation of ester and/or disulfide linkages between the siRNA and hydrogels, which is independent ...[more]