The Landscape of Genetic Content in the Gut and Oral Human Microbiome.
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ABSTRACT:
SUBMITTER: Tierney BT
PROVIDER: S-EPMC6716383 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
The Landscape of Genetic Content in the Gut and Oral Human Microbiome.
Tierney Braden T BT Yang Zhen Z Luber Jacob M JM Beaudin Marc M Wibowo Marsha C MC Baek Christina C Mehlenbacher Eleanor E Patel Chirag J CJ Kostic Aleksandar D AD
Cell host & microbe 20190801 2
Despite substantial interest in the species diversity of the human microbiome and its role in disease, the scale of its genetic diversity, which is fundamental to deciphering human-microbe interactions, has not been quantified. Here, we conducted a cross-study meta-analysis of metagenomes from two human body niches, the mouth and gut, covering 3,655 samples from 13 studies. We found staggering genetic heterogeneity in the dataset, identifying a total of 45,666,334 non-redundant genes (23,961,508 ...[more]
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