Ontology highlight
ABSTRACT:
SUBMITTER: Silvestre-Roig C
PROVIDER: S-EPMC6716525 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Silvestre-Roig Carlos C Braster Quinte Q Wichapong Kanin K Lee Ernest Y EY Teulon Jean Marie JM Berrebeh Nihel N Winter Janine J Adrover José M JM Santos Giancarlo Santiago GS Froese Alexander A Lemnitzer Patricia P Ortega-Gómez Almudena A Chevre Raphael R Marschner Julian J Schumski Ariane A Winter Carla C Perez-Olivares Laura L Pan Chang C Paulin Nicole N Schoufour Tom T Hartwig Helene H González-Ramos Silvia S Kamp Frits F Megens Remco T A RTA Mowen Kerri A KA Gunzer Matthias M Maegdefessel Lars L Hackeng Tilman T Lutgens Esther E Daemen Mat M von Blume Julia J Anders Hans-Joachim HJ Nikolaev Viacheslav O VO Pellequer Jean-Luc JL Weber Christian C Hidalgo Andrés A Nicolaes Gerry A F GAF Wong Gerard C L GCL Soehnlein Oliver O
Nature 20190501 7755
The perpetuation of inflammation is an important pathophysiological contributor to the global medical burden. Chronic inflammation is promoted by non-programmed cell death<sup>1,2</sup>; however, how inflammation is instigated, its cellular and molecular mediators, and its therapeutic value are poorly defined. Here we use mouse models of atherosclerosis-a major underlying cause of mortality worldwide-to demonstrate that extracellular histone H4-mediated membrane lysis of smooth muscle cells (SMC ...[more]