Dataset Information

Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity.

ABSTRACT: Proper transcriptome reprogramming is critical for hosts to launch an effective defense response upon pathogen attack. How immune-related genes are regulated at the posttranscriptional level remains elusive. We demonstrate here that P-bodies, the non-membranous cytoplasmic ribonucleoprotein foci related to 5'-to-3' mRNA decay, are dynamically modulated in plant immunity triggered by microbe-associated molecular patterns (MAMPs). The DCP1-DCP2 mRNA decapping complex, a hallmark of P-bodies, positively regulates plant MAMP-triggered responses and immunity against pathogenic bacteria. MAMP-activated MAP kinases directly phosphorylate DCP1 at the serine237 residue, which further stimulates its interaction with XRN4, an exonuclease executing 5'-to-3' degradation of decapped mRNA. Consequently, MAMP treatment potentiates DCP1-dependent mRNA decay on a specific group of MAMP-downregulated genes. Thus, the conserved 5'-to-3' mRNA decay elicited by the MAMP-activated MAP kinase cascade is an integral part of plant immunity. This mechanism ensures a rapid posttranscriptional downregulation of certain immune-related genes that may otherwise negatively impact immunity.

SUBMITTER: Yu X

PROVIDER: S-EPMC6716526 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity.

Yu Xiao X Li Bo B Jang Geng-Jen GJ Jiang Shan S Jiang Daohong D Jang Jyan-Chyun JC Wu Shu-Hsing SH Shan Libo L He Ping P

Cell reports 20190801 8

Proper transcriptome reprogramming is critical for hosts to launch an effective defense response upon pathogen attack. How immune-related genes are regulated at the posttranscriptional level remains elusive. We demonstrate here that P-bodies, the non-membranous cytoplasmic ribonucleoprotein foci related to 5'-to-3' mRNA decay, are dynamically modulated in plant immunity triggered by microbe-associated molecular patterns (MAMPs). The DCP1-DCP2 mRNA decapping complex, a hallmark of P-bodies, posit ...[more]

PMID: 31433992

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Dataset Information

Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity.

Publications

Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity.

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