Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC6717262 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Chen Shuo S Wu Jiale J Zhong Shan S Li Yuntong Y Zhang Ping P Ma Jingyi J Ren Jingshan J Tan Yun Y Wang Yunhao Y Au Kin Fai KF Siebold Christian C Bond Gareth L GL Chen Zhu Z Lu Min M Jones E Yvonne EY Lu Xin X
Proceedings of the National Academy of Sciences of the United States of America 20190808 35
The most frequently mutated protein in human cancer is p53, a transcription factor (TF) that regulates myriad genes instrumental in diverse cellular outcomes including growth arrest and cell death. Cell context-dependent p53 modulation is critical for this life-or-death balance, yet remains incompletely understood. Here we identify sequence signatures enriched in genomic p53-binding sites modulated by the transcription cofactor iASPP. Moreover, our p53-iASPP crystal structure reveals that iASPP ...[more]