Ontology highlight
ABSTRACT:
SUBMITTER: Hu J
PROVIDER: S-EPMC6717279 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Hu Jiliang J Li Yiwei Y Hao Yukun Y Zheng Tianqi T Gupta Satish K SK Parada German Alberto GA Wu Huayin H Lin Shaoting S Wang Shida S Zhao Xuanhe X Goldman Robert D RD Cai Shengqiang S Guo Ming M
Proceedings of the National Academy of Sciences of the United States of America 20190813 35
In many developmental and pathological processes, including cellular migration during normal development and invasion in cancer metastasis, cells are required to withstand severe deformations. The structural integrity of eukaryotic cells under small deformations has been known to depend on the cytoskeleton including actin filaments (F-actin), microtubules (MT), and intermediate filaments (IFs). However, it remains unclear how cells resist severe deformations since both F-actin and microtubules y ...[more]