Ontology highlight
ABSTRACT:
SUBMITTER: Saunthararajah Y
PROVIDER: S-EPMC6717594 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Haematologica 20190808 9
The complex, frequently devastating, multi-organ pathophysiology of sickle cell disease has a single root cause: polymerization of deoxygenated sickle hemoglobin. A logical approach to disease modification is, therefore, to interdict this root cause. Ideally, such interdiction would utilize small molecules that are practical and accessible for worldwide application. Two types of such small molecule strategies are actively being evaluated in the clinic. The first strategy intends to shift red blo ...[more]