Ontology highlight
ABSTRACT:
SUBMITTER: Brouwer M
PROVIDER: S-EPMC6717895 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Brouwer Marinka M Farzana Fatima F Koopmans Frank F Chen Ning N Brunner Jessie W JW Oldani Silvia S Li Ka Wan KW van Weering Jan Rt JR Smit August B AB Toonen Ruud F RF Verhage Matthijs M Verhage Matthijs M
The EMBO journal 20190801 17
Synapse development requires spatiotemporally regulated recruitment of synaptic proteins. In this study, we describe a novel presynaptic mechanism of cis-regulated oligomerization of adhesion molecules that controls synaptogenesis. We identified synaptic adhesion-like molecule 1 (SALM1) as a constituent of the proposed presynaptic Munc18/CASK/Mint1/Lin7b organizer complex. SALM1 preferentially localized to presynaptic compartments of excitatory hippocampal neurons. SALM1 depletion in excitatory ...[more]