Ontology highlight
ABSTRACT:
SUBMITTER: Smola M
PROVIDER: S-EPMC6718146 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Smola Miroslav M Birkus Gabriel G Boura Evzen E
Acta crystallographica. Section F, Structural biology communications 20190828 Pt 9
Stimulator of interferon genes (STING) binds cyclic dinucleotides (CDNs), which induce a large conformational change of the protein. The structural basis of activation of STING by CDNs is rather well understood. Unliganded STING forms an open dimer that undergoes a large conformational change (∼10 Å) to a closed conformation upon the binding of a CDN molecule. This event activates downstream effectors of STING and subsequently leads to activation of the type 1 interferon response. However, a pre ...[more]