Ontology highlight
ABSTRACT:
SUBMITTER: Lv X
PROVIDER: S-EPMC6718393 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lv Xiaohui X Ren Si-Qiang SQ Zhang Xin-Jun XJ Shen Zhongfu Z Ghosh Tanay T Xianyu Anjin A Gao Peng P Li Zhizhong Z Lin Susan S Yu Yang Y Zhang Qiangqiang Q Groszer Matthias M Shi Song-Hai SH
Nature communications 20190902 1
Cerebral cortex expansion is a hallmark of mammalian brain evolution; yet, how increased neurogenesis is coordinated with structural and functional development remains largely unclear. The T-box protein TBR2/EOMES is preferentially enriched in intermediate progenitors and supports cortical neurogenesis expansion. Here we show that TBR2 regulates fine-scale spatial and circuit organization of excitatory neurons in addition to enhancing neurogenesis in the mouse cortex. TBR2 removal leads to a sig ...[more]