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Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK.

ABSTRACT: Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of convergence and extension (CE) movements in Xenopus laevis. XPAPC functions as a signalling molecule that coordinates cell polarity of the involuting mesoderm in mediolateral orientation and thus selectively promotes convergence in CE movements. XPAPC signals through the small GTPases Rho A and Rac 1 and c-jun N-terminal kinase (JNK). Loss of XPAPC function blocks Rho A-mediated JNK activation. Despite common downstream components, XPAPC and Wnt/PCP signalling are not redundant, and the activity of both, XPAPC and PCP signalling, is required to coordinate CE movements.

SUBMITTER: Unterseher F

PROVIDER: S-EPMC514506 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature

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Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK.

Unterseher Frank F Hefele Joerg A JA Giehl Klaudia K De Robertis Eddy M EM Wedlich Doris D Schambony Alexandra A

The EMBO journal 20040805 16

Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of convergence and extension (CE) movements in Xenopus laevis. XPAPC functions as a signalling molecule that coordinates cell polarity of the involuting mesoderm in mediolateral orientation and thus selectively ...[more]

PMID: 15297873

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