Ontology highlight
ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC6718415 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Yang Chao C Siebert Jason R JR Burns Robert R Gerbec Zachary J ZJ Bonacci Benedetta B Rymaszewski Amy A Rau Mary M Riese Matthew J MJ Rao Sridhar S Carlson Karen-Sue KS Routes John M JM Verbsky James W JW Thakar Monica S MS Malarkannan Subramaniam S
Nature communications 20190902 1
Natural killer (NK) cells are critical to both innate and adaptive immunity. However, the development and heterogeneity of human NK cells are yet to be fully defined. Using single-cell RNA-sequencing technology, here we identify distinct NK populations in human bone marrow and blood, including one population expressing higher levels of immediate early genes indicative of a homeostatic activation. Functionally matured NK cells with high expression of CX3CR1, HAVCR2 (TIM-3), and ZEB2 represents te ...[more]