Tumor-reprogrammed resident T cells resist radiation to control tumors.
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ABSTRACT:
SUBMITTER: Arina A
PROVIDER: S-EPMC6718618 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Tumor-reprogrammed resident T cells resist radiation to control tumors.
Arina Ainhoa A Beckett Michael M Fernandez Christian C Zheng Wenxin W Pitroda Sean S Chmura Steven J SJ Luke Jason J JJ Forde Martin M Hou Yuzhu Y Burnette Byron B Mauceri Helena H Lowy Israel I Sims Tasha T Khodarev Nikolai N Fu Yang-Xin YX Weichselbaum Ralph R RR
Nature communications 20190902 1
Successful combinations of radiotherapy and immunotherapy depend on the presence of live T cells within the tumor; however, radiotherapy is believed to damage T cells. Here, based on longitudinal in vivo imaging and functional analysis, we report that a large proportion of T cells survive clinically relevant doses of radiation and show increased motility, and higher production of interferon gamma, compared with T cells from unirradiated tumors. Irradiated intratumoral T cells can mediate tumor c ...[more]
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