Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression.
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ABSTRACT:
SUBMITTER: Elam KK
PROVIDER: S-EPMC6718657 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression.
Elam Kit K KK Clifford Sierra S Shaw Daniel S DS Wilson Melvin N MN Lemery-Chalfant Kathryn K
Translational psychiatry 20190902 1
Previous approaches for creating polygenic risk scores (PRSs) do not explicitly consider the biological or developmental relevance of the genetic variants selected for inclusion. We applied gene set enrichment analysis to meta-GWAS data to create developmentally targeted, functionally informed PRSs. Using two developmentally matched meta-GWAS discovery samples, separate PRSs were formed, then examined in time-varying effect models of aggression in a second, longitudinal sample of children (n = 5 ...[more]
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