Ontology highlight
ABSTRACT:
SUBMITTER: van Drogen F
PROVIDER: S-EPMC6719448 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
van Drogen Frank F Mishra Ranjan R Rudolf Fabian F Walczak Michal J MJ Lee Sung Sik SS Reiter Wolfgang W Hegemann Björn B Pelet Serge S Dohnal Ilse I Binolfi Andres A Yudina Zinaida Z Selenko Philipp P Wider Gerhard G Ammerer Gustav G Peter Matthias M
The Journal of cell biology 20190717 9
Cells continuously adapt cellular processes by integrating external and internal signals. In yeast, multiple stress signals regulate pheromone signaling to prevent mating under unfavorable conditions. However, the underlying crosstalk mechanisms remain poorly understood. Here, we show that mechanical stress activates Pkc1, which prevents lysis of pheromone-treated cells by inhibiting polarized growth. In vitro Pkc1 phosphorylates conserved residues within the RING-H2 domains of the scaffold prot ...[more]