Dataset Information

Cardiovascular fitness and risk of migraine: a large, prospective population-based study of Swedish young adult men.

ABSTRACT:

Objectives

To examine the longitudinal relationship between cardiovascular fitness in young adult men and future risk of migraine and to estimate eventual differential effects among categories of body mass index (BMI) and blood pressure.

Design

National, prospective, population-based cohort study.

Setting

Sweden 1968-2014.

Participants

18-year-old Swedish men (n=1 819 828) who underwent mandatory military conscription examinations during the years 1968-2005.

Primary and secondary outcomes

The primary outcome was the first dispensation of prescribed migraine-specific medication, identified using the Swedish Prescribed Drug Register. The secondary outcome was documented migraine diagnosis from the Swedish National Hospital Register.

Results

During follow-up, 22 533 men filled a prescription for migraine-specific medication. After confounding adjustment, compared with high cardiovascular fitness, low and medium fitness increased the risk of migraine-specific medication (risk ratio (RR)_low: 1.29, 95%?CI 1.24 to 1.35; population attributable fraction: 3.6%, 95%?CI 1.7% to 5.3% and RR_medium: 1.15, 95%?CI 1.12 to 1.19; population attributable fraction: 8.0%, 95%?CI 4.0% to 11.7%). To assess potential effect measure modification, stratified analyses of these association by levels of BMI and blood pressure showed that lower fitness levels increased risk of migraine across all groups except among underweight men or men with high diastolic blood pressure.

Conclusions

Young men with a lower cardiovascular fitness had a higher long-term risk of developing pharmacological prescription-requiring migraine. This study contributes with information regarding risk factors for migraine in men, an understudied population in migraine research.

SUBMITTER: Nyberg J

PROVIDER: S-EPMC6719773 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Cardiovascular fitness and risk of migraine: a large, prospective population-based study of Swedish young adult men.

Nyberg Jenny J Gustavsson Sara S Linde Mattias M Åberg N David ND Rohmann Jessica L JL Åberg Maria M Kurth Tobias T Waern Margda M Kuhn Georg Hans GH

BMJ open 20190830 8

<h4>Objectives</h4>To examine the longitudinal relationship between cardiovascular fitness in young adult men and future risk of migraine and to estimate eventual differential effects among categories of body mass index (BMI) and blood pressure.<h4>Design</h4>National, prospective, population-based cohort study.<h4>Setting</h4>Sweden 1968-2014.<h4>Participants</h4>18-year-old Swedish men (n=1 819 828) who underwent mandatory military conscription examinations during the years 1968-2005.<h4>Prima ...[more]

PMID: 31473616

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Project description:The purpose of this study was to clarify the causes of the smoking-schizophrenia association.Using Cox proportional hazard and co-relative control models, the authors predicted future risk for a diagnosis of schizophrenia or nonaffective psychosis from the smoking status of 1,413,849 women and 233,879 men from, respectively, the Swedish birth and conscript registries.Smoking was assessed in women at a mean age of 27 and in men at a mean age of 18. The mean age at end of follow-up was 46 for women and 26 for men. Hazard ratios for first-onset schizophrenia were elevated both for light smoking (2.21 [95% CI=1.90-2.56] for women and 2.15 [95% CI=1.25-3.44] for men) and heavy smoking (3.45 [95% CI=2.95-4.03] for women and 3.80 [95% CI=1.19-6.60] for men). These associations did not decline when schizophrenia onsets 3-5 years after smoking assessment were censored. When age, socioeconomic status, and drug abuse were controlled for, hazard ratios declined only modestly in both samples. Women who smoked into late pregnancy had a much higher risk for schizophrenia than those who quit early. Hazard ratios predicting nonaffective psychosis in the general population, in cousins, in half siblings, and in full siblings discordant for heavy smoking were, respectively, 2.67, 2.71, 2.54, and 2.18. A model utilizing all relative pairs predicted a hazard ratio of 1.69 (95% CI=1.17-2.44) for nonaffective psychosis in the heavy-smoking member of discordant monozygotic twin pairs.Smoking prospectively predicts risk for schizophrenia. This association does not arise from smoking onset during a schizophrenic prodrome and demonstrates a clear dose-response relationship. While little of this association is explained by epidemiological confounders, a portion arises from common familial/genetic risk factors. However, in full siblings and especially monozygotic twins discordant for smoking, risk for nonaffective psychosis is appreciably higher in the smoking member. These results can help in evaluating the plausibility of various etiological hypotheses for the smoking-schizophrenia association.

Dataset Information

Cardiovascular fitness and risk of migraine: a large, prospective population-based study of Swedish young adult men.

Objectives

Design

Setting

Participants

Primary and secondary outcomes

Results

Conclusions

Publications

Cardiovascular fitness and risk of migraine: a large, prospective population-based study of Swedish young adult men.

Similar Datasets

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