Ontology highlight
ABSTRACT:
SUBMITTER: Okesli-Armlovich A
PROVIDER: S-EPMC6719797 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Okesli-Armlovich Ayse A Gupta Amita A Jimenez Marta M Auld Douglas D Liu Qi Q Bassik Michael C MC Khosla Chaitan C
Bioorganic & medicinal chemistry letters 20190807 18
Clinically relevant inhibitors of dihydroorotate dehydrogenase (DHODH), a rate-limiting enzyme in mammalian de novo pyrimidine synthesis, have strong antiviral and anticancer activity in vitro. However, they are ineffective in vivo due to efficient uridine salvage by infected or rapidly dividing cells. The pyrimidine salvage enzyme uridine-cytidine kinase 2 (UCK2), a ∼29 kDa protein that forms a tetramer in its active state, is necessary for uridine salvage. Notwithstanding the pharmacological p ...[more]