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Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities.


ABSTRACT: Five new cucurbitane-typetriterpenoid glycosides, named Xuedanoside F-J (1-5), were obtained from the rhizomes of Hemsleya penxianensis (Xue dan), which belongs to the family of Cucurbitaceae. These new compounds were elucidated byspectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS spectra. Additionally, all the isolates were evaluated for cytotoxicity against three human cancer cell lines (Hela, MCF-7, and A-549) with the IC50 ranging from 2.25 to 49.44 µM in vitro with treatment 48 h and showed low cytotoxicity in human normal liver L-02 cells (IC50 > 50 µM). Compound 5 showed the most significant cytotoxic activity with the IC50 value of 2.25, 4.72, and 5.33 µM in 48 h, respectively.

SUBMITTER: Chen DL 

PROVIDER: S-EPMC6720345 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of <i>Hemsleya penxianensis</i> with Cytotoxic Activities.

Chen De-Li DL   Xu Xu-Dong XD   Li Rong-Tao RT   Wang Bo-Wen BW   Yu Meng M   Liu Yang-Yang YY   Ma Guo-Xu GX  

Molecules (Basel, Switzerland) 20190813 16


Five new cucurbitane-typetriterpenoid glycosides, named Xuedanoside F-J (<b>1</b>-<b>5</b>), were obtained from the rhizomes of <i>Hemsleya penxianensis</i> (Xue dan), which belongs to the family of Cucurbitaceae. These new compounds were elucidated byspectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS spectra. Additionally, all the isolates were evaluated for cytotoxicity against three human cancer cell lines (Hela, MCF-7, and A-549) with the IC<sub>50</sub> ranging from 2.25 to 49.44 µ  ...[more]

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