Ontology highlight
ABSTRACT:
SUBMITTER: Park W
PROVIDER: S-EPMC6720534 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Park Wonjin W Baek Yi-Yong YY Kim Joohwan J Jo Dong Hyun DH Choi Seunghwan S Kim Jin Hyoung JH Kim Taesam T Kim Suji S Park Minsik M Kim Ji Yoon JY Won Moo-Ho MH Ha Kwon-Soo KS Kim Jeong Hun JH Kwon Young-Guen YG Kim Young-Myeong YM
Biomolecules & therapeutics 20190901 5
Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the therapeutic mechanisms and effects of the tetrapeptide Arg-Leu-Tyr-Glu (RLYE), a VEGFR2 inhibitor, in the development of vascular permeability and choroidal neovascularization (CNV). In cultured human retinal microvascular endothelial cells (HRMECs), treatment with RLYE blocked VEGF-A-indu ...[more]