Ontology highlight
ABSTRACT:
SUBMITTER: Hwang DE
PROVIDER: S-EPMC4807815 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Hwang Da-Eun DE Ryou Jeong-Hyun JH Oh Jong Rok JR Han Jung Woo JW Park Tae Kwann TK Kim Hak-Sung HS
PloS one 20160325 3
Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness among people over the age of 60. Vascular endothelial growth factor (VEGF) plays a major role in pathological angiogenesis in AMD. Herein, we present the development of an anti- human VEGF repebody, which is a small-sized protein binder consisting of leucine-rich repeat (LRR) modules. The anti-VEGF repebody selected through a phage-display was shown to have a high affinity and specificity for human VEGF. We ...[more]