Ontology highlight
ABSTRACT:
SUBMITTER: Mendes A
PROVIDER: S-EPMC6721129 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Mendes Aline A Meneghetti Maria C Z MCZ Palladino Marcelly Valle MV Justo Giselle Zenker GZ Sassaki Guilherme L GL Fareed Jawed J Lima Marcelo A MA Nader Helena B HB
Molecules (Basel, Switzerland) 20190817 16
Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety of heparin, since in 2008, adverse effects associated with the presence of an oversulfated chondroitin sulfate (OSCS) were observed in preparations of pharmaceutical porcine heparin, which led to the death of patients, causing a global public health crisis. However, it has not been clarified whether OSCS has been added to the purified hepar ...[more]