Kinetics of Intratumoral Immune Cell Activation During Chemoradiation for Cervical Cancer.

ABSTRACT:

Purpose

Radiation therapy has direct cytotoxic effects on tumor-infiltrating lymphocytes, but it also has immune stimulatory effects that increase immune cell infiltration. The dynamics of these competing effects on immune cells at the site of the tumor are poorly characterized during chemoradiation treatment (CRT) because of the difficulty of obtaining consecutive tumor biopsies. We used a minimally invasive cervical cytobrushing method to analyze the kinetics of intratumoral immune cell changes in patients with cervical cancer during CRT.

Methods and materials

Cervical brushings were obtained from 20 patients with cervical cancer at baseline and during fractionated radiation therapy and cisplatin (weeks 1, 3, and 5). Matching peripheral blood mononuclear cells were obtaine

SUBMITTER: Dorta-Estremera S 

PROVIDER: S-EPMC6721616 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature