Ontology highlight
ABSTRACT:
SUBMITTER: Nocita E
PROVIDER: S-EPMC6721729 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nocita Emanuela E Del Giovane Alice A Tiberi Marta M Boccuni Laura L Fiorelli Denise D Sposato Carola C Romano Elena E Basoli Francesco F Trombetta Marcella M Rainer Alberto A Traversa Enrico E Ragnini-Wilson Antonella A
Cells 20190806 8
Remyelination in the adult brain relies on the reactivation of the Neuronal Precursor Cell (NPC) niche and differentiation into Oligodendrocyte Precursor Cells (OPCs) as well as on OPC maturation into myelinating oligodendrocytes (OLs). These two distinct phases in OL development are defined by transcriptional and morphological changes. How this differentiation program is controlled remains unclear. We used two drugs that stimulate myelin basic protein (MBP) expression (Clobetasol and Gefitinib) ...[more]