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Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41.


ABSTRACT: Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant strains has led to the increased failure of ARDs, thus calling for the development of anti-HIV drugs with targets or mechanisms of action different from those of the current ARDs. The first peptide-based HIV entry inhibitor, enfuvirtide, was approved by the U.S. FDA in 2003 for treatment of HIV/AIDS patients who have failed to respond to the current ARDs, which has stimulated the development of several series of protein- and peptide-based HIV entry inhibitors in preclinical and clinical studies. In this review, we highlighted the properties and mechanisms of action for those promising protein- and peptide-based HIV entry inhibitors targeting the HIV-1 gp120 or gp41 and discussed their advantages and disadvantages, compared with the current ARDs.

SUBMITTER: Pu J 

PROVIDER: S-EPMC6722851 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41.

Pu Jing J   Wang Qian Q   Xu Wei W   Lu Lu L   Jiang Shibo S  

Viruses 20190801 8


Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant strains has led to the increased failure of ARDs, thus calling for the development of anti-HIV drugs with targets or mechanisms of action different from those of the current ARDs. The first peptide-based HIV entry inhibitor, enfuvirtide, was approved by the U.S. FDA in 2003 for treatment of HIV/AIDS patients who have f  ...[more]

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