Ontology highlight
ABSTRACT:
SUBMITTER: Pu J
PROVIDER: S-EPMC6722851 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Pu Jing J Wang Qian Q Xu Wei W Lu Lu L Jiang Shibo S
Viruses 20190801 8
Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant strains has led to the increased failure of ARDs, thus calling for the development of anti-HIV drugs with targets or mechanisms of action different from those of the current ARDs. The first peptide-based HIV entry inhibitor, enfuvirtide, was approved by the U.S. FDA in 2003 for treatment of HIV/AIDS patients who have f ...[more]