Ontology highlight
ABSTRACT:
SUBMITTER: Curreli F
PROVIDER: S-EPMC6446940 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Curreli Francesca F Belov Dmitry S DS Ahmed Shahad S Ramesh Ranjith R RR Kurkin Alexander V AV Altieri Andrea A Debnath Asim K AK
ChemMedChem 20181019 21
The pathway by which HIV-1 enters host cells is a prime target for novel drug discovery because of its critical role in the life cycle of HIV-1. The HIV-1 envelope glycoprotein gp120 plays an important role in initiating virus entry by targeting the primary cell receptor CD4. We explored the substitution of bulky molecular groups in region I in the NBD class of entry inhibitors. Previous attempts at bulky substituents in that region abolished antiviral activity, even though the binding site is h ...[more]