Ontology highlight
ABSTRACT:
SUBMITTER: Peet MM
PROVIDER: S-EPMC6723036 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Peet M Melissa MM Agrahari Vivek V Anderson Sharon M SM Hanif Homaira H Singh Onkar N ON Thurman Andrea R AR Doncel Gustavo F GF Clark Meredith R MR
Pharmaceutics 20190801 8
The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP) dosage forms. They may be used for vaginal and/or rectal administration of a variety of agents with antiviral activity. Topical inserts deliver drugs to the portal of viral entry, i.e., the genital or rectal mucosa, with low systemic exposure, and therefore are sa ...[more]