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Potentials of Host-Directed Therapies in Tuberculosis Management.

ABSTRACT: Tuberculosis (TB) remains as a leading cause of mortality in developing countries, persisting as a major threat to the global public health. Current treatment involving a long antibiotic regimen brings concern to the topic of patient compliance, contributing to the emergence of drug resistant TB. The current review will provide an updated outlook on novel anti-TB therapies that can be given as adjunctive agents to current anti-TB treatments, with a particular focus on modulating the host immune response to effectively target all forms of TB. Additional potential therapeutic pathway targets, including lipid metabolism alteration and vascular endothelial growth factor (VEGF)-directed therapies, are discussed.

SUBMITTER: Dara Y

PROVIDER: S-EPMC6723166 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Potentials of Host-Directed Therapies in Tuberculosis Management.

Dara Yash Y Volcani Doron D Shah Kush K Shin Kevin K Venketaraman Vishwanath V

Journal of clinical medicine 20190803 8

Tuberculosis (TB) remains as a leading cause of mortality in developing countries, persisting as a major threat to the global public health. Current treatment involving a long antibiotic regimen brings concern to the topic of patient compliance, contributing to the emergence of drug resistant TB. The current review will provide an updated outlook on novel anti-TB therapies that can be given as adjunctive agents to current anti-TB treatments, with a particular focus on modulating the host immune ...[more]

PMID: 31382631

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