Ontology highlight
ABSTRACT:
SUBMITTER: Pei J
PROVIDER: S-EPMC6723868 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Pei Jiayi J Juni Rio R Harakalova Magdalena M Duncker Dirk J DJ Asselbergs Folkert W FW Koolwijk Pieter P Hinsbergh Victor van VV Verhaar Marianne C MC Mokry Michal M Cheng Caroline C
Toxins 20190802 8
Indoxyl sulfate (IS) is an accumulative protein-bound uremic toxin found in patients with kidney disease. It is reported that IS impairs the vascular endothelium, but a comprehensive overview of all mechanisms active in IS-injury currently remains lacking. Here we performed RNA sequencing in human umbilical vein endothelial cells (HUVECs) after IS or control medium treatment and identified 1293 genes that were affected in a IS-induced response. Gene enrichment analysis highlighted pathways invol ...[more]