Trends in the Explanatory or Pragmatic Nature of Cardiovascular Clinical Trials Over 2 Decades.

ABSTRACT:

Importance

Pragmatic trials test interventions using designs that produce results that may be more applicable to the population in which the intervention will be eventually applied.

Objective

To investigate how pragmatic or explanatory cardiovascular (CV) randomized clinical trials (RCT) are, and if this has changed over time.

Data source

Six major medical and CV journals, including New England Journal of Medicine, Lancet, JAMA, Circulation, European Heart Journal, and Journal of the American College of Cardiology.

Study selection

All CV-related RCTs published during 2000, 2005, 2010, and 2015 were identified and included.

Data extraction and synthesis

Included RCTs were assessed by 2 independent adjudicators with expertise in RCT and CV medicine.

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SUBMITTER: Sepehrvand N 

PROVIDER: S-EPMC6724414 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature