Tissue-engineered 3D microvessel and capillary network models for the study of vascular phenomena.
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ABSTRACT:
SUBMITTER: Bogorad MI
PROVIDER: S-EPMC6726128 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Tissue-engineered 3D microvessel and capillary network models for the study of vascular phenomena.
Bogorad Max I MI DeStefano Jackson J Wong Andrew D AD Searson Peter C PC
Microcirculation (New York, N.Y. : 1994) 20170701 5
Advances in tissue engineering, cell biology, microfabrication, and microfluidics have led to the development of a wide range of vascular models. Here, we review platforms based on templated microvessel fabrication to generate increasingly complex vascular models of (i) the tumor microenvironment, (ii) occluded microvessels, and (iii) perfused capillary networks. We outline fabrication guidelines and demonstrate a number of experimental methods for probing vascular function such as permeability ...[more]
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