Ontology highlight
ABSTRACT:
SUBMITTER: Deleuze C
PROVIDER: S-EPMC6726197 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Deleuze Charlotte C Bhumbra Gary S GS Pazienti Antonio A Lourenço Joana J Mailhes Caroline C Aguirre Andrea A Beato Marco M Bacci Alberto A
PLoS biology 20190904 9
Parvalbumin (PV)-positive interneurons modulate cortical activity through highly specialized connectivity patterns onto excitatory pyramidal neurons (PNs) and other inhibitory cells. PV cells are autoconnected through powerful autapses, but the contribution of this form of fast disinhibition to cortical function is unknown. We found that autaptic transmission represents the most powerful inhibitory input of PV cells in neocortical layer V. Autaptic strength was greater than synaptic strength ont ...[more]