Ontology highlight
ABSTRACT:
SUBMITTER: O'Brown NM
PROVIDER: S-EPMC6726461 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
eLife 20190820
As an optically transparent model organism with an endothelial blood-brain barrier (BBB), zebrafish offer a powerful tool to study the vertebrate BBB. However, the precise developmental profile of functional zebrafish BBB acquisition and the subcellular and molecular mechanisms governing the zebrafish BBB remain poorly characterized. Here, we capture the dynamics of developmental BBB leakage using live imaging, revealing a combination of steady accumulation in the parenchyma and sporadic bursts ...[more]