Ontology highlight
ABSTRACT:
SUBMITTER: Beard R
PROVIDER: S-EPMC7006505 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Beard Rhiannon R Gaboriau David C A DCA Gee Antony D AD Tate Edward W EW
Chemical science 20191008 46
Absorptive- and receptor-mediated transcytosis (AMT/RMT) are widely studied strategies to deliver therapeutics across the blood-brain barrier (BBB). However, an improved understanding of the mechanism surrounding trafficking is required that could promote delivery. Accordingly, we designed a flexible platform that merged AMT and RMT motifs on a single scaffold to probe various parameters (ligand, affinity, valency, position) in a screening campaign. During this process we adapted an <i>in vitro< ...[more]