Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC6726519 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Chen Justin J Haanpää Maria K MK Gruber Joshua J JJ Jäger Natalie N Ford James M JM Snyder Michael P MP
Clinical cancer research : an official journal of the American Association for Cancer Research 20190607 17
<h4>Purpose</h4>Understanding and explaining hereditary predisposition to cancer has focused on the genetic etiology of the disease. However, mutations in known genes associated with breast cancer, such as <i>BRCA1</i> and <i>BRCA2</i>, account for less than 25% of familial cases of breast cancer. Recently, specific epigenetic modifications at <i>BRCA1</i> have been shown to promote hereditary breast cancer, but the broader potential for epigenetic contribution to hereditary breast cancer is not ...[more]