Ontology highlight
ABSTRACT:
SUBMITTER: Lai PK
PROVIDER: S-EPMC6726534 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Biotechnology and bioengineering 20190721 10
Proline-rich antimicrobial peptides (PrAMPs) kill bacteria via a nonlytic mechanism in which they permeate through the outer membrane, utilize protein-mediated transport across the inner membrane, and target the ribosome to inhibit protein synthesis. We previously reported that substitutions of oncocin ( VDKPPYLPRPRPPRRIYNR-NH2 ) with a pair of cationic residues improved the antimicrobial activity. In this study, we applied the design protocol to three other PrAMPs: apidaecin-1b, pyrrhocoricin, ...[more]