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Synthesis of a new series of 2-hydroxy-5-iodo-N'-(1-arylethylidene)benzohydrazides using a deep eutectic solvent as solvent/catalyst under sonication.

ABSTRACT: We report here the preparation of 2-hydroxy-5-iodo-N'-(1-arylethylidene)benzohydrazide compounds in good to excellent yields (83-98%) within a short reaction time (10-15 min), through a clean and efficient procedure. Seventeen new compounds were synthesized and fully characterized by FT-IR, NMR, and HRMS. The deep eutectic solvent can be recovered easily by phase extraction and can be reused up to several times without any significant loss of catalytic activity. Additionally, the method has a wide substrate scope and provides an accessible route for the large-scale direct synthesis of 2-hydroxy-5-iodo-N'-(1-arylethylidene)benzohydrazides.

SUBMITTER: Nguyen TT

PROVIDER: S-EPMC6726719 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Synthesis of a new series of 2-hydroxy-5-iodo-<i>N</i>'-(1-arylethylidene)benzohydrazides using a deep eutectic solvent as solvent/catalyst under sonication.

Nguyen The Thai TT Nguyen Cong Tien CT Tran Phuong Hoang PH

Heliyon 20190831 8

We report here the preparation of 2-hydroxy-5-iodo-<i>N</i>'-(1-arylethylidene)benzohydrazide compounds in good to excellent yields (83-98%) within a short reaction time (10-15 min), through a clean and efficient procedure. Seventeen new compounds were synthesized and fully characterized by FT-IR, NMR, and HRMS. The deep eutectic solvent can be recovered easily by phase extraction and can be reused up to several times without any significant loss of catalytic activity. Additionally, the method h ...[more]

PMID: 31508526

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