Ontology highlight
ABSTRACT:
SUBMITTER: Kim HJ
PROVIDER: S-EPMC6727136 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Kim Hyeon J HJ Wei Ying Y Wojtkiewicz Gregory R GR Lee Ji Y JY Moskowitz Michael A MA Chen John W JW
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20180420 9
Myeloperoxidase (MPO) is a pro-inflammatory enzyme abundantly secreted by activated myeloid cells after stroke. We show that when MPO activity is either blocked by the specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) in wildtype (WT) mice or congenitally absent (MPO<sup>-/-</sup>), there was decreased cell loss, including degenerating neurons and oligodendrocytes, in the ischemic brains compared to vehicle-treated WT mice after stroke. MPO inhibition also reduced the number of activated m ...[more]