A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury.

ABSTRACT:

Background

GATA3 is a dual-zinc finger transcription factor that regulates gene expression in many developing tissues. In the kidney, GATA3 is essential for ureteric bud branching, and mice without it fail to develop kidneys. In humans, autosomal dominant GATA3 mutations can cause renal aplasia as part of the hypoparathyroidism, renal dysplasia, deafness (HDR) syndrome that includes mesangioproliferative GN. This suggests that GATA3 may have a previously unrecognized role in glomerular development or injury.

Methods

To determine GATA3's role in glomerular development or injury, we assessed GATA3 expression in developing and mature kidneys from Gata3 heterozygous (⁺/-) knockout mice, as well as injured human and rodent kidneys.

Results

We show

SUBMITTER: Grigorieva IV 

PROVIDER: S-EPMC6727249 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature