Ontology highlight
ABSTRACT:
SUBMITTER: Alhadeff AL
PROVIDER: S-EPMC6728176 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Alhadeff Amber L AL Goldstein Nitsan N Park Onyoo O Klima Michelle L ML Vargas Alexandra A Betley J Nicholas JN
Neuron 20190702 5
Motivated behavior is influenced by neural networks that integrate physiological needs. Here, we describe coordinated regulation of hypothalamic feeding and midbrain reward circuits in awake behaving mice. We find that alcohol and other non-nutritive drugs inhibit activity in hypothalamic feeding neurons. Interestingly, nutrients and drugs utilize different pathways for the inhibition of hypothalamic neuron activity, as alcohol signals hypothalamic neurons in a vagal-independent manner, while fa ...[more]