Ontology highlight
ABSTRACT:
SUBMITTER: Figueiredo CP
PROVIDER: S-EPMC6728367 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Figueiredo Claudia P CP Barros-Aragão Fernanda G Q FGQ Neris Rômulo L S RLS Frost Paula S PS Soares Carolina C Souza Isis N O INO Zeidler Julianna D JD Zamberlan Daniele C DC de Sousa Virginia L VL Souza Amanda S AS Guimarães André Luis A ALA Bellio Maria M Marcondes de Souza Jorge J Alves-Leon Soniza V SV Neves Gilda A GA Paula-Neto Heitor A HA Castro Newton G NG De Felice Fernanda G FG Assunção-Miranda Iranaia I Clarke Julia R JR Da Poian Andrea T AT Ferreira Sergio T ST
Nature communications 20190905 1
Neurological complications affecting the central nervous system have been reported in adult patients infected by Zika virus (ZIKV) but the underlying mechanisms remain unknown. Here, we report that ZIKV replicates in human and mouse adult brain tissue, targeting mature neurons. ZIKV preferentially targets memory-related brain regions, inhibits hippocampal long-term potentiation and induces memory impairment in adult mice. TNF-α upregulation, microgliosis and upregulation of complement system pro ...[more]