Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank.
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ABSTRACT:
SUBMITTER: Zhao JV
PROVIDER: S-EPMC6728387 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank.
Zhao Jie V JV Luo Shan S Schooling C Mary CM
Communications biology 20190905
Insulin drives growth and reproduction which trade-off against longevity. Genetically predicted insulin, i.e., insulin proxied by genetic variants, is positively associated with ischemic heart disease, but sex differences are unclear, despite different disease rates and reproductive strategies by sex. We used Mendelian randomization in 392,010 white British from the UK Biobank to assess the sex-specific role of genetically predicted insulin in myocardial infarction (MI) (14,442 cases, 77% men), ...[more]
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