Association between genetically predicted telomere length and facial skin aging in the UK Biobank: a Mendelian randomization study.

ABSTRACT: Are shorter telomeres causal risk factors for facial aging on a large population level? To examine if longer, genetically predicted telomeres were causally associated with less facial aging using Mendelian randomization analysis. Two-sample Mendelian randomization methods were applied to the summary statistics of a genome-wide association study (GWAS) for self-reported facial aging from 417, 772 participants of the UK Biobank data. Twenty single-nucleotide polymorphisms (SNPs) that were of genome-wide significance were selected as instrumental variables for leukocyte telomere length. The main analyses were performed primarily using the random-effects inverse-variance weighted method and were complemented with the MR-Egger regression, weighted median, and weighted mode approaches. The inter

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC8190204 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature