Ontology highlight
ABSTRACT:
SUBMITTER: Ono F
PROVIDER: S-EPMC6729331 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Ono Fumihito F Mandel Gail G Brehm Paul P
The Journal of neuroscience : the official journal of the Society for Neuroscience 20040601 24
Clustering of nicotinic muscle acetylcholine receptors (AChRs) requires association with intracellular rapsyn, a protein with an intrinsic ability to self-cluster. Previous studies on sofa potato (sop), an AChR null line of zebrafish, have suggested that AChRs may play an active role in subsynaptic localization of rapsyn clusters. To test this proposal directly, we identified and cloned the gene responsible for the sop phenotype and then attempted to rescue subsynaptic localization of the recept ...[more]