Ontology highlight
ABSTRACT:
SUBMITTER: Rappert A
PROVIDER: S-EPMC6729901 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Rappert Angelika A Bechmann Ingo I Pivneva Tatyana T Mahlo Jacqueline J Biber Knut K Nolte Christiane C Kovac Adam D AD Gerard Craig C Boddeke Hendrikus W G M HW Nitsch Robert R Kettenmann Helmut H
The Journal of neuroscience : the official journal of the Society for Neuroscience 20040901 39
Microglia are the resident macrophage population of the CNS and are considered its major immunocompetent elements. They are activated by any type of brain pathology and can migrate to the lesion site. The chemokine CXCL10 is expressed in neurons in response to brain injury and is a signaling candidate for activating microglia and directing them to the lesion site. We recently identified CXCR3, the corresponding receptor for CXCL10, in microglia and demonstrated that this receptor system controls ...[more]