Unknown

Dataset Information

0

Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina.


ABSTRACT: Melatonin is synthesized in retinal photoreceptor cells and acts as a neuromodulator imparting photoperiodic information to the retina. The synthesis of melatonin is controlled by an ocular circadian clock and by light in a finely tuned mechanism that ensures that melatonin is synthesized and acts only at night in darkness. Here we report that the circadian clock gates melatonin synthesis in part by regulating the expression of the type 1 adenylyl cyclase (AC1) and the synthesis of cAMP in photoreceptor cells. This gating is effected through E-box-mediated transcriptional activation of the AC1 gene, which undergoes robust daily fluctuations that persist in constant illumination. The circadian control of the cAMP signaling cascade indicates that the clock has a more general and profound impact on retinal functions than previously thought. In addition, rhythmic control of AC1 expression was observed in other parts of the central circadian axis, the suprachiasmatic nucleus and pineal gland, but not in other brain areas examined. Thus, clock control of the cAMP signaling cascade may play a central role in the integration of circadian signals that control physiology and behavior.

SUBMITTER: Fukuhara C 

PROVIDER: S-EPMC6730387 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina.

Fukuhara Chiaki C   Liu Cuimei C   Ivanova Tamara N TN   Chan Guy C-K GC   Storm Daniel R DR   Iuvone P Michael PM   Tosini Gianluca G  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040201 8


Melatonin is synthesized in retinal photoreceptor cells and acts as a neuromodulator imparting photoperiodic information to the retina. The synthesis of melatonin is controlled by an ocular circadian clock and by light in a finely tuned mechanism that ensures that melatonin is synthesized and acts only at night in darkness. Here we report that the circadian clock gates melatonin synthesis in part by regulating the expression of the type 1 adenylyl cyclase (AC1) and the synthesis of cAMP in photo  ...[more]

Similar Datasets

| S-EPMC4159264 | biostudies-literature
| S-EPMC6725211 | biostudies-literature
| S-EPMC2040024 | biostudies-literature
| S-EPMC1480470 | biostudies-literature
| S-EPMC7453030 | biostudies-literature
| S-EPMC2553039 | biostudies-literature
| S-EPMC1367307 | biostudies-literature
| S-EPMC5501165 | biostudies-literature
| S-EPMC2653556 | biostudies-literature
| S-EPMC3946763 | biostudies-literature