Dataset Information

Burden of influenza-associated respiratory hospitalizations in the Americas, 2010-2015.

ABSTRACT: BACKGROUND:Despite having influenza vaccination policies and programs, countries in the Americas underutilize seasonal influenza vaccine, in part because of insufficient evidence about severe influenza burden. We aimed to estimate the annual burden of influenza-associated respiratory hospitalizations in the Americas. METHODS:Thirty-five countries in the Americas with national influenza surveillance were invited to provide monthly laboratory data and hospital discharges for respiratory illness (International Classification of Diseases 10th edition J codes 0-99) during 2010-2015. In three age-strata (<5, 5-64, and ?65 years), we estimated the influenza-associated hospitalizations rate by multiplying the monthly number of respiratory hospitalizations by the monthly proportion of influenza-positive samples and dividing by the census population. We used random effects meta-analyses to pool age-group specific rates and extrapolated to countries that did not contribute data, using pooled rates stratified by age group and country characteristics found to be associated with rates. RESULTS:Sixteen of 35 countries (46%) contributed primary data to the analyses, representing 79% of the America's population. The average pooled rate of influenza-associated respiratory hospitalization was 90/100,000 population (95% confidence interval 61-132) among children aged <5 years, 21/100,000 population (13-32) among persons aged 5-64 years, and 141/100,000 population (95-211) among persons aged ?65 years. We estimated the average annual number of influenza-associated respiratory hospitalizations in the Americas to be 772,000 (95% credible interval 716,000-829,000). CONCLUSIONS:Influenza-associated respiratory hospitalizations impose a heavy burden on health systems in the Americas. Countries in the Americas should use this information to justify investments in seasonal influenza vaccination-especially among young children and the elderly.

SUBMITTER: Palekar RS

PROVIDER: S-EPMC6730873 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Burden of influenza-associated respiratory hospitalizations in the Americas, 2010-2015.

Palekar Rakhee S RS Rolfes Melissa A MA Arriola C Sofia CS Acosta Belsy O BO Guidos Patricia Alberto PA Vargas Xiomara Badilla XB Bancej Christina C Ramirez Juliana Barbosa JB Baumeister Elsa E Bruno Alfredo A Cabello Maria Agüeda MA Chen Jufu J Couto Paula P Junior Francisco J De Paula FJP Fasce Rodrigo R Ferreira de Almeida Walquiria W Solorzano Victor E Fiesta VEF Ramírez Carlos Flores CF Goñi Natalia N Isaza de Moltó Yadira Y Lara Jenny J Malo Diana C DC Medina Osis José L JL Mejía Homer H Castillo Lourdes Moreno LM Mustaquim Desiree D Nwosu Andrea A Ojeda Jenny J Samoya Antonio Paredes AP Pulido Paola A PA Ramos Hernandez Hector M HM Lopez Rudvelinda Rivera RR Rodriguez Angel A Saboui Myriam M Bolanos Hilda Salazar HS Santoro Adrián A Silvera Jose Eduardo JE Sosa Paulina P Sotomayor Viviana V Suarez Lourdes L Von Horoch Marta M Azziz-Baumgartner Eduardo E

PloS one 20190906 9

<h4>Background</h4>Despite having influenza vaccination policies and programs, countries in the Americas underutilize seasonal influenza vaccine, in part because of insufficient evidence about severe influenza burden. We aimed to estimate the annual burden of influenza-associated respiratory hospitalizations in the Americas.<h4>Methods</h4>Thirty-five countries in the Americas with national influenza surveillance were invited to provide monthly laboratory data and hospital discharges for respira ...[more]

PMID: 31490961

Similar Datasets

Project description:ObjectiveInfluenza is the most common vaccine-preventable disease in the United States; however, little is known about the burden of critical illness due to influenza virus infection. Our primary objective was to estimate the proportion of all critical illness hospitalizations that are attributable to seasonal influenza.DesignRetrospective cohort study.SettingArizona, California, and Washington from January 2003 to March 2009.PatientsAll adults hospitalized with critical illness, defined by International Classification of Diseases, 9th Edition, Clinical Modification diagnosis and procedure codes for acute respiratory failure, severe sepsis, or in-hospital death.Measurements and main resultsWe combined the complete hospitalization discharge databases for three U.S. states, regional influenza virus surveillance, and state census data. Using negative binomial regression models, we estimated the incidence rates of adult influenza-associated critical illness hospitalizations and compared them with all-cause event rates. We also compared modeled outcomes to International Classification of Diseases, 9th Edition, Clinical Modification-coded influenza hospitalizations to assess potential underrecognition of severe influenza disease. During the study period, we estimated that 26,760 influenza-associated critical illness hospitalizations (95% CI, 14,541, 47,464) occurred. The population-based incidence estimate for influenza-associated critical illness was 12.0 per 100,000 person-years (95% CI, 6.6, 21.6) or 1.3% of all critical illness hospitalizations (95% CI, 0.7%, 2.3%). During the influenza season, 3.4% of all critical illness hospitalizations (95% CI, 1.9%, 5.8%) were attributable to influenza. There were only 2,612 critical illness hospitalizations with International Classification of Diseases, 9th Edition, Clinical Modification-coded influenza diagnoses, suggesting influenza is either undiagnosed or undercoded in a substantial proportion of critical illness.ConclusionsExtrapolating our data to the 2010 U.S. population, we estimate that about 28,000 adults are hospitalized for influenza-associated critical illness annually. Influenza in many of these critically ill patients may be undiagnosed. Critical care physicians should have a high index of suspicion for influenza in the ICU, particularly when influenza is known to be circulating in their communities.

Dataset Information

Burden of influenza-associated respiratory hospitalizations in the Americas, 2010-2015.

Publications

Burden of influenza-associated respiratory hospitalizations in the Americas, 2010-2015.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets